Methyl Calcium L-5-Methyltetrahydrofolate (L-5-MTHF-Ca)

• CAS No.: 151533-22-1
• Formula: C20h23can7o6
• EINECS: N/a
• Packaging Material: Tin
• Storage Method: Normal
• Shelf Life: 6 Months-12 Months
• Model NO.: AWI
• Nutrient Composition: Amino Acid
• Product Name: Calcium L-5-Methyltetrahydrofolate
• Quality Standard: USP
• Packing: 0.5 Kg Tin
• Appearance: White to Light Yellow Crystalline Powder
• Transport Package: 1kg Bags/25kg Carton or as Client′s Demand
• Trademark: AWI
• Origin: China
• Production Capacity: 200 Metric Ton/Metric Tons Per Month

Product Description

Product Name	Calcium L-5-Methyltetrahydrofolate
Batch Number	20190802	Quantity	5kgs
Quality Standard	USP	Packing	0.5 kg/tin
Manufacture Date	2019.07.25	Expiry Date	2021.07.24

Application and Uses 

L-5-MTHF-Ca (5-mthf) is a naturally occurring salt-forming methyl derivative of folic acid. 5-mthf is also known as levomethyl-folate, which is the most biologically active and functional of folic acid. Form, more easily absorbed than ordinary folic acid. Common folic acid must be converted to type 1 methyl folate to participate in two major metabolic pathways: methylation and DNA synthesis, the only form of free folate normally present in human plasma and cells is 5-mthf. Lack of folic acid is usually caused by vitamin deficiency, which is insufficient for absorption. 

 

Application:

1. Mainly for folic acid antagonists (such as methotrexate, pyrimethamine, benzyl cefalexin and trimethoprim) antidote, it's usually used for prevention of methotrexate dose or overdose treatment caused severe toxic effects.

2. as adjuvant therapy for colon cancer, rectal cancer

3. Combined with 5-FU and treatment of digestive tract tumors or other 5-FU-sensitive tumors. High-dose CF used in conjunction with 5-FU (LF), the basic programme is currently the treatment of colon and rectal cancer.
 

 

 

Item		Standard	Test Result
Appearance		White to light yellow crystalline powder	Conforms
Specific rotation                 (on anhydrous substance)		[α]^25D(C=1.5% in water)	+40.6°
Identification	HNMR	HNMR should be identical with that of reference	Conforms
	HPLC	The retention time of the major peak in the chromatogram of Assay preparation corresponds to that in the chromatogram of the standard preparation,as obtained in the Assay	Conforms
Calcium content (on anhydrous substance)		7.0%~8.5%	7.7%
D-5-Methylfolate		≤1.0%	Undetected
(HPLC) Related compounds	Dimethyltetrahydrofolic acid	≤0.15%	0.07%
	Single Impurity	≤1.0%	0.23%
	Total Impurity	≤2.5%	0.94%
Residual solvent	Ethanol	NMT 5000ppm	Undetected
Water		≤16.0%	14.7%
Chloride(CI)		≤0.5%	Conforms
Arsenic(As)		≤1ppm	<1ppm
Boron		≤20ppm	Conforms
Heavy Metals		NMT 20ppm Pb NMT 1ppm Cd NMT 0.5ppm As NMT 1.5ppm Hg NMT 1.5 ppm	Conforms
Total Plate Count		≤100cfu/g	Conforms
Yeast & Mold		≤100cfu/g	No detected
Salmonella		Negative	No detected
E.Coli		Negative	No detected
Purity		>97.5%	99.1%
Conclusion		This batch of product complies to the standard.

 

AWI Service

1. Supply high quality products with a reasonable price.
2. Keep shipment in time, provide complete customers clearance documents as customs request. 
3. Provide agile and safe payments.
4. We will responsible for all quality issue.
5. Share marketing informations with customers update price in time.
 

FAQ

1. What's your payment terms?
T/T, D/P, L/C, O/A
2. What's your delivery time?
Usually we will arrange the shipment within 14 days.
3. How about the packing? 
Usually with 25 kg bag/carton/drum. 
4. How about the validity of the products? 
Usually 2 or 3 years. 
5. What documents you provide? 
Usually, Commerical Invoice, Packing List, Country of Origin, Insurance Policy, Bill of loading, COA , Health certificate. 
6. What is loading port?
Usually, Qingdao, Tianjin and Shanghai  

Amy Xu 

High-Tech Industry Development Zone,Hefei,China
Welcome meet us at:
Fi Africa 15-17 March 2020 at Cairo Egypt. AWI Booth # H1.D46.
Fi Vietnam 1-3 July 2020 at HCMC Vietnam. AWI Booth # A1.112.